The Benefits of Niacinamide Mononucleotide (NMN)

NMN, also called nicotinamide adenine dinucleotide, is a naturally occurring molecule. It is believed to help boost energy supply in the body, reduce the risk of obesity, and improve insulin sensitivity. The benefits of NMN have been demonstrated in animal studies, and more human trials are underway.

NMN is a precursor to NAD+, a molecule that helps fight aging. It has been shown to help increase production of the coenzyme, which is essential to life.

Researchers found that the supplementation of NMN increased serum levels of NAD+ by 38 percent. This resulted in greater aerobic capacity and better sleep.

NMN appears to be absorbed into the cell via a transporter protein. Slc12a8 has been identified as a key part of the transporter. It dials up automatically when NAD+ levels fall, making it possible to deliver NMN directly into the cells.

In addition to boosting energy supply, NMN may help in combating age-related diseases. Research suggests that NMN has a protective effect on telomeres, which shorten after cell division. In a mouse model, NMN helped to stabilize telomeres.

It has also been shown to decrease fat mass and increase lean mass. This makes NMN a potentially beneficial therapy for age-related weight gain.

There are several ways to produce NMN. Chemical synthesis is one of the simplest. The method is inexpensive and requires only a few steps. The NMN produced can be separated and purified to further enhance its purity.

Scientists are still investigating the effects of NMN on glucose metabolism and other factors. While a recent clinical trial in Japan showed a safe and effective way of delivering NMN into the body, more research is needed to make definitive claims.