NMN, nicotinamide mononucleotide, is a vitamin D3 derivative. It has been shown to improve insulin sensitivity and suppress age-related weight gain. It also helps to improve the body’s ability to repair and regenerate DNA. It is a natural product found in many food sources. It is used in dietary supplements to increase the levels of NAD+ in the body.
NMN is a precursor of nicotinamide adenine dinucleotide (NAD+), a hydride-accepting coenzyme, which plays important roles in cellular energy production. It has been shown that increased levels of NAD+ correlate with higher levels of mitochondrial function, which leads to improved endurance and overall health. NMN is also used in cosmetic skin care compositions.
Studies have shown that NMN has the ability to slow the progression of age-related skin problems. Moreover, NMN has been found to help maintain elasticity and prevent rough skin. It is also believed that NMN is transported across cell membranes by the Slc12a8 transporter.
In addition to its anti-aging potential, NMN may also have a positive effect on cognitive health. For example, a study has shown that niacin, a nicotinamide precursor, improved spatial learning and modified neurological severity scores in normal mice. Similarly, nicotinamide riboside, a nicotinamide-containing metabolite, has been found to reduce age-related hearing loss and restore outer hair cells.
NMN is also thought to play a role in NAD+ biosynthesis. It is one of three precursors for the synthesis of nicotinamide adenine phosphate (NADPH), which is the reduced form of nicotinamide adenine Dinucleotide (NAD).
NMN can be produced using yeast. This is because it has a very short molecular size and is easily diffused into the cells.