Nicotinamide mononucleotide (NMN) is a molecule that is found in many tissues in the body. It is a cofactor that helps in the production of nicotinamide adenine dinucleotide (NAD+). NAD+ is needed for the body to produce energy. It also protects the DNA from oxidative damage. It is also used by enzymes that perform cellular functions.
NMN is an essential molecule in the fight against aging. It is a precursor for NAD+, which is a redox coenzyme that is important for metabolism and may have protective properties against cancer and other age-related conditions. It also helps regulate blood sugar levels and helps to protect the heart from injury.
In a clinical study, NMN was metabolized safely in healthy male subjects. The safety of NMN is governed by its metabolization by the liver. Doses higher than the recommended dosage for humans have not been studied.
The primary objective of this study was to evaluate the effects of NMN on body composition. Dose-dependent reductions in body weight were achieved with NMN. The results indicated a significant decrease in total body weight. The reduction was observed at a 100-mg/kg dose, while at 300-mg/kg, the effect was slightly larger.
No adverse effects were reported with the single oral dose of 500 mg NMN or the 12-week chronic administration of 250 mg of NMN. The effects of NMN on heart rate and blood pressure were not significant. A mixed-effect model was used to compare the mean values of the NMN and placebo groups.