NMN, the precursor of NAD+, has been investigated as a health product to delay the aging process. Scientists believe that NMN supplementation can help people live longer and more productive lives.
NMN is thought to be effective in preventing age-related diseases, improving muscle endurance, and increasing cellular energy. However, NMN has not been approved by the FDA for consumption as a dietary supplement.
Researchers are conducting clinical trials to investigate the safety and effectiveness of NMN supplements. Safety concerns have been identified, but more studies are needed to determine how much NMN is safe for long-term administration.
Manufacturers are aggressively marketing NMN products. They use in vitro results to sell their products, but more clinical studies are required to establish the safety of NMN in humans.
The most recent study by Keio University School of Medicine in Japan, for example, evaluated the bioavailability and blood levels of NMN. NMN supplementation in healthy volunteers was found to be safe. Blood pressure, body temperature, and oxygen saturation were not affected by NMN.
There are other studies in which NMN is shown to have anti-aging effects. For example, NMN has been shown to increase NAD+ levels in ovarian tissue, improve fertility, and prevent age-related gene expression changes.
NMN supplementation has also been shown to have beneficial therapeutic effects on heart failure and age-induced type 2 diabetes. In mice, NMN restored NAD+ levels and reinstated mitochondrial function. NMN also reversed age-related physiological decline.
Currently, the only way to get NMN into the body is through a transporter protein called Slc12a8. This protein is automatically dialed up by cells when NAD+ levels decrease.