Resveratrol is a polyphenol that is commonly found in red wines and grapes. It has many biological properties, including antioxidant, antibacterial, anti-inflammatory and chemopreventive properties. Some of these properties have been attributed to its interaction with the NF-kB transcription factor.

NF-kB protein is known to play a key role in regulating gene expression and cell proliferation. High resveratrol doses decrease mitotic activity in tumor cells, while low resveratrol doses promote cell proliferation.

Resveratrol is a type of stilbenoid polyphenol. The phenol rings in the molecule are linked by an ethylene bridge. This structure allows for the presence of an ethene ring, which enables the molecule to have an antioxidant activity.

Several clinical studies have suggested that resveratrol may have implications in the pathology of several diseases. Resveratrol is known to exhibit cytostatic/apoptotic effects, including inhibition of the nuclear translocation of the NF-kB transcription factor. In addition, resveratrol exhibits antitumor and cardioprotective properties. Moreover, resveratrol has been reported to inhibit the acetylation of NF-kB, thereby inhibiting its ability to make cancer cells resistant to chemotherapy.

Resveratrol is known to interact with cytochrome P450, which is a part of the detoxification system of the body. Taking high resveratrol intakes may increase the risk of toxicity. Moreover, high resveratrol intakes can also reduce the metabolic clearance of drugs, which could result in increased drug toxicities.

Trans-resveratrol is a better quality and more stable form of resveratrol than cis-resveratrol. However, it is important to find a supplement that contains 98%+ purity.