NMN anti aging supplementation has gained popularity as the research on the substance has continued. However, safety issues have raised concerns.
Researchers believe NMN will improve energy levels, reduce inflammation, and maintain the integrity of the blood brain barrier. It has also shown therapeutic effects on heart failure and age-induced type 2 diabetes.
Nicotinamide riboside (NR) prevents hearing loss in mice and also restores outer hair cells. In another study, NR enhanced insulin sensitivity. NR has recently been granted GRAS status by the FDA.
NMN is a precursor of NAD+, the main cellular energy source. Increasing NAD+ levels increases energy and may promote DNA repair.
Studies have been conducted in the lab, in cell culture, and in animal models. However, there are still not enough human clinical studies to confirm the effectiveness and safety of NMN in humans. A third clinical study is ongoing at the University of Tokyo Hospital.
The initial hypothesis was that NMN would provide cellular energy. However, most of the research has been done in animal models and in cell culture.
Scientists can measure a tissue’s age by using various indicators. For instance, a younger mouse is likely to be more responsive to NMN than a more aged one.
In addition to cardiovascular performance and reducing inflammation, NMN has been linked to the treatment of Alzheimer’s disease. The protective effects of NMN treatments are expected to be mediated by mitochondrial rejuvenation pathways and anti-inflammatory genes.
NMN has been used in the treatment of type II diabetes, obesity, cardiac ischemia, and cerebral ischemia. Although the substance has proven safe in animal models, it remains unclear how safe it is for humans.